产品详情介绍
CD81也称TAPA-1，是四跨膜蛋白超家族（TM4SF）成员之一，广泛表达于真核细胞膜，与其他四跨膜蛋白、整合素、辅助受体、MHC I类和II类分子形成复合物，并影响B、T细胞的粘附、形态、活化、增殖和分化[1-4]。在肌肉中，CD81促进细胞融合和肌管维护[5]。CD81也是一种表征明显的丙型肝炎病毒受体，可促进病毒入侵靶细胞[6]。本产品为小鼠抗人CD81单克隆抗体，用于IF和FC方法特异性检测人CD81蛋白。
CD系列产品介绍视频
[1] Levy S, Todd SC, Maecker HT. CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system [J]. Annu Rev
Immunol. 1998, 16: 89-109.
[2] van Zelm MC, Smet J, Adams B, et al. CD81 gene defect in humans disrupts CD19 complex formation and leads to antibody deficiency [J]. J Clin
Invest. 2010, 120(4): 1265-74.
[3] Cherukuri A, Carter RH, Brooks S, et al. B Cell Signaling Is Regulated by Induced Palmitoylation of CD81 [J]. Journal of Biological Chemistry. 2004,
279(30): 31973-82.
[4] Sagi Y, Landrigan A, Levy R, et al. Complementary costimulation of human T-cell subpopulations by cluster of differentiation 28 (CD28) and CD81
[J]. Proceedings of the National Academy of Sciences. 2012, 109(5): 1613-8.
[5] Charrin S, Latil M, Soave S, et al. Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81 [J]. Nat
Commun. 2013, 4: 1674.
[6] Bartosch B, Vitelli A, Granier C, et al. Cell Entry of Hepatitis C Virus Requires a Set of Co-receptors That Include the CD81 Tetraspanin and the
SR-B1 Scavenger Receptor [J]. Journal of Biological Chemistry. 2003, 278(43): 41624-30.
