产品详情介绍
CD9属于细胞表面糖蛋白四跨膜蛋白家族。CD9在发育中的B淋巴细胞、血小板、单核细胞、嗜酸性粒细胞、嗜碱性粒细胞、受刺激的T淋巴细胞以及周围神经系统的神经元和胶质细胞表面都有表达[1-3]。在成肌细胞中，CD9与CD81和PTGFRN协同作用，在肌肉再生过程中抑制肌管融合。在巨噬细胞中，与CD81、β-1和β-2整合素协同作用，阻止巨噬细胞融合为多核巨细胞[4]。CD9在许多细胞生理过程中还发挥重要作用，包括分化、粘附和信号转导，它在抑制癌细胞运动和转移中起着关键作用[5,6]。本产品为小鼠抗人CD9单克隆抗体，用于IF和FC方法特异性检测人CD9蛋白。
CD系列产品介绍视频
[1] Reyes R, Cardeñes B, Machado-Pineda Y, et al. Tetraspanin CD9: A Key Regulator of Cell Adhesion in the Immune System [J]. Front Immunol. 2018, 9: 863.
[2] Jennings LK, Crossno JT Jr, Fox CF, et al. Platelet p24/CD9, a member of the tetraspanin family of proteins [J]. Ann N Y Acad Sci. 1994, 714(1): 175-84.
[3] Nakamura Y, Iwamoto R, Mekada E. Expression and distribution of CD9 in myelin of the central and peripheral nervous systems [J]. Am J Pathol. 1996, 149(2): 575-83.
[4] Takeda Y, Tachibana I, Miyado K, et al. Tetraspanins CD9 and CD81 function to prevent the fusion of mononuclear phagocytes [J]. Journal of Cell Biology. 2003, 161(5): 945-56.
[5] Ikeyama S, Koyama M, Yamaoko M, et al. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA [J]. J Exp Med. 1993, 177(5): 1231-7.
[6] Masellis-Smith A, Shaw AR. CD9-regulated adhesion. Anti-CD9 monoclonal antibody induce pre-B cell adhesion to bone marrow fibroblasts through de novo recognition of fibronectin [J]. J Immunol. 1994, 152(6): 2768-77.
